Drug Resistance

More Patients Presenting with Lamivudine-Resistant Hepatitis B

Published in Hepatitis Weekly, October 30th, 2000

According to a research report published in the Journal of Hepatology, medical personnel who take care of patients with hepatitis B virus (HBV) are beginning to see more and more patients with viral strains that are resistant to lamivudine therapy.

Lamivudine has been used to treat patients with HBV for several years now. Unfortunately, some HBV virus strains have acquired mutations that make them non-susceptible to the drug that has been a mainstay for treating HBV patients.

"In the majority of lamivudine-resistant isolates, the mutations have been reported to occur within the YMDD motif of the viral polymerase, either as a single mutation...

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Source: Hepatitis Weekly (2000-10-30)

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