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Immunology

Viral Persistence Critical for CNS Retention of CD8+ Cells in Animal Model

Published in Hepatitis Weekly, October 30th, 2000

CD8+ T cells remain in the spinal cord and central nervous system (CNS) structures for an extended period of time after a bout of encephalomyelitis, scientists report. However, these cells only remain in the CNS for as long as the virus continues to persist in the host, according to a study performed by researchers in California.

Research investigators at the University of Southern California's Keck School of Medicine used an animal model to demonstrate this causal relationship between virus persistence and CD8+ T cells ("Role of viral persistence in retaining CD8+ T cells within the central nervous system," Journal of Virology,...

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