Disease Associations

Helicobacter hepaticus Not a Factor for Disease in IL-10 Deficient Mice

Published in Hepatitis Weekly, October 30th, 2000

Mice lacking the gene for expressing interleukin (IL)-10 are not highly susceptible to Helicobacter hepaticus infection, nor do they experience any greater degree of colitis or other associated symptoms of that sort any more than IL-10 positive mice do, scientists report.

"H. hepaticus has been reported to induce colitis, hepatitis, and hepatocellular carcinoma in several different murine models," commented L.A. Dieleman and colleagues in the report.

However, results of experiments performed by Dieleman et al. show that IL-10 deficiency does not correlate with a significant level of pathogenesis in H. hepaticus inoculated...

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Source: Hepatitis Weekly (2000-10-30)

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