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Hepatitis B Vaccines

DNA Vaccine Stimulates Unique Immunogenicity

Published in Hepatitis Weekly, November 13th, 2000

A hepatitis B virus (HBV) DNA vaccine stimulates immunomodulatory responses and may have therapeutic benefit, researchers in Hong Kong report.

"HBsAg [hepatitis B surface antigen] encoded in eukaryotically expressed plasmids has been documented to elicit good humoral and cellular immune responses when injected in animals, and is a good candidate for immunization of non-responders of recombinant HBsAg vaccines and for therapeutic vaccination," stated L.P. Wong and colleagues from the University of Hong Kong. "Live-attenuated Salmonella is safe to be administered orally, and has been shown to be able to deliver DNA vaccines. [We sought] to evaluate the...

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