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Hepatotoxicity

Capsaicin, Neurokinin Receptor Antagonist Protect Against Hepatitis in Mice

Published in Hepatitis Weekly, January 8th, 2001

Capsaicin and a neurokinin-1-receptor antagonist have shown hepatoprotective properties in a mouse model.

Both substances appear to protect mice from hepatitis by depleting peptidergic primary afferents, according to a report presented at the 30th Annual Meeting of the Society for Neuroscience by medical investigators at the University of Erlangen-Nurnberg in Germany.

G. Tiegs et al. reported that mice with lipopolysaccharide (LPS) or tumor necrosis factor (TNF)-alpha induced liver injury were completely protected from liver damage by the prior administration of capsaicin. Capsaicin depletes substance P in nerve endings.

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