Liver Cancer

Cells in Diabetic Mice Resist Tumor Necrosis Factor Induced Lethality

Published in Hepatitis Weekly, January 29th, 2001

Tumor necrosis factor (TNF)-alpha and D-galactosamine are lethal to the liver cells of normal laboratory mice. In non-obese diabetic mice however, liver cells resist apoptosis and lethality. A report published in the Journal of Immunology suggests this increased resistance is caused by a post-TNF receptor (TNFR) binding defect.

In a study comparing C57BL/6J (B6) mice and non-obese diabetic (NOD) mice, "NOD mice were at least 100-fold more resistant to recombinant human TNF-alpha and D-galactosamine treatment than B6 mice," reported F.R. Bahjat and colleagues at the University of Florida. Other experiments had already demonstrated reduced apoptotic activity,...

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Source: Hepatitis Weekly (2001-01-29)

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