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Hepatocyte Transplantation

Scientists Repopulate Rat Livers With Transplanted Liver Cells

Published in Hepatitis Weekly, March 5th, 2001

by Sonia Nichols, staff medical writer -- Researchers in the U.S. and Italy have been able to grow new liver cells in rats by transplanting the rats with donor hepatocytes.

The prospect of being able to perform this feat in humans would be a huge leap forward in treating patients with various liver ailments.

"A strategy for hepatocyte transplantation was recently developed whereby massive replacement of the recipient liver is achieved after a combined treatment with retrorsine, a pyrrolizidine alkaloid, and partial hepatectomy," S. Laconi and colleages explained.

To deduce whether repopulation could occur in the absence of...

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