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Pathogenesis

Differential Profiles Mark Genetics Of Hepatitis B And C

Published in Hepatitis Weekly, March 26th, 2001

by Sonia Nichols, staff medical writer - Scientists have found clues that genetic mechanisms differ in hepatitis B and hepatitis C virus infections.

The scientists, members of a research team at Kanazawa University in Japan, have used complementary DNA (cDNA) microarray technology to study genetic differences in tissue lesions of patients with chronic hepatitis B or C. Their research suggests differential expression of genes that control inflammatory factors influence the body's response to hepatitis B virus (HBV) or hepatitis C virus (HCV).

"We made cDNA microarrays consisting of 1080 human cDNAs and analyzed gene expression using labeled cDNAs...

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