Pathogenesis

Hepatitis D Virus Takes Over Transcription

Published in Hepatitis Weekly, June 11th, 2001

Researchers have discovered how hepatitis delta virus (HDV), an RNA virus that strengthens the disease associated with the hepatitis B virus, makes use of its host's transcription machinery, specifically RNA polymerase II.

Details of this molecular manipulation could aid researchers in developing drug designs against HDV.

Yuki Yamaguchi and colleagues in Japan found that the sequence of hepatitis delta antigen is similar to a subunit of a human protein called NELF, which inhibits transcription elongation by RNA polymerase II ("Stimulation of RNA polymerase II elongation by hepatitis delta antigen," Science, May 31, 2001).

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Source: Hepatitis Weekly (2001-06-11)

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