Hepatitis C Virus

Reason For Enzyme Level Elevation During Interferon Therapy Still A Mystery

Published in Hepatitis Weekly, February 4th, 2002

by Sonia Nichols, senior medical writer - Doctors still can't explain why levels of the liver enzyme alanine aminotransferase (ALT) may rise in some chronic hepatitis C patients on interferon (IFN)-(beta) therapy despite reduced viremia.

A research team in Japan recently attempted to answer that question by analyzing several patients given standard regimens of IFN-(beta), but their analysis left many questions unanswered.

In the study, 109 chronic hepatitis C patients received 6 MU doses of IFN-(beta) daily for up to 12 weeks. "When serum ALT levels during the therapy were higher than three times the level before the therapy, liver biopsy was...

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Source: Hepatitis Weekly (2002-02-04)

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