End-stage Liver Disease

Potential therapy reported for children, adults

Published in Hepatitis Weekly, June 10th, 2002

A Johns Hopkins Children's Center scientist reports success in animal studies in preventing a cascade of brain pathology that appears to both cause and signal the final and fatal stages of acute and chronic liver disease in children and adults. The findings appeared in the journal Medicine (Balitmore) (Hyperammonemic encepalopathy, Medicine (Balitmore), 2002;81(3):240-249).

In the review article, pediatric biochemical geneticist Saul Brusilow, MD, wrote that the chemical methionine sulfoximine (MSO) appears to prevent the brain swelling (encephalopathy) in patients with acute liver failure. It is the swelling, he believes, that causes pressure on the...

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Source: Hepatitis Weekly (2002-06-10)

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