Viral Construction

Molecular wedge could lead normal virus formation astray in hepatitis B

Published in Hepatitis Weekly, June 17th, 2002

by Sonia Nichols, senior medical writer - Small molecules that act like secret agents could be key to disrupting the formation of hepatitis B and other viruses, suggest researchers at the University of Oklahoma.

The scientists think a molecule known as bis-ANS and others like it could form the underpinnings for new types of antiviral agents in the future.

Explaining that HBV capsids can be produced in the lab, Adam Zlotnick and colleagues at the University of Oklahoma Health Sciences Center recently described in the Journal of Virology how bis-ANS acts as a wedge to disrupt capsid assembly. After binding to capsid building blocks, the...

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Source: Hepatitis Weekly (2002-06-17)

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