Liver Cancer

Sector of hepatitis C virus may interrupt work of cancer prevention gene

Published in Hepatitis Weekly, August 19th, 2002

by Sonia Nichols, senior medical writer - The findings of a new study are pointing to the NS5A protein of hepatitis C virus (HCV) as an inhibitor of p53-mediated apoptosis.

Normally the p53 protein could suppress tumor formation by inducing programmed cell death, or apoptosis. However, scientists have now found evidence that NS5A may interact with p53 to block that effect, igniting cancer growth.

"HCV NS5A binds directly to p53 and colocalizes p53 in the perinuclear region," said K-H. Lan and colleagues of the protein interaction. Lan, of the Taipei Veterans General Hospital and National Yang-Ming University School of Medicine in Taiwan, was one of...

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Source: Hepatitis Weekly (2002-08-19)

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