Hepatocellular Carcinoma

Woodchuck hepatitis virus replication diminishes in preneoplastic lesions

Published in Hepatitis Weekly, November 11th, 2002

by Sonia Nichols, senior medical writer - Preneoplastic lesions in animals infected with a virus similar to hepatitis B virus (HBV) don't contain very many replicating virions, scientists have learned.

Woodchuck hepatitis virus (WHV) infects animals such as woodchucks, and is similar to HBV with respect to its virology. New tests of precancerous liver lesions in woodchucks have shown that few contain replicative intermediates, according to researchers in Heidelberg, Germany.

HBV is a well-known risk factor for hepatocellular carcinoma. In woodchucks, such virus-related cancers are derived from two different preneoplastic lineages and contain two...

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Source: Hepatitis Weekly (2002-11-11)

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