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Hepatocellular Carcinoma

Antisense nucleotides keep cancer cell proliferation in check

Published in Hepatitis Weekly, November 25th, 2002

by Sonia Nichols, senior medical writer - Some day, one of the most common forms of cancer in the world could be treated with synthetic nucleotides.

Scientists know that hepatoma-derived growth factor energizes the proliferation of liver cancer cells. They suspect that antisense oligonucleotides could be used for blocking hepatoma growth factor expression, which would in turn block cancer growth.

Studies of antisense oligonucleotide to hepatoma-derived growth factor have proven it slows liver cancer cell proliferation in several cell lines, according to Y. Kishima and colleagues, Osaka University Graduate School of Medicine, Osaka, Japan.

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