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Hepatocellular Carcinoma

New evidence disfavors tamoxifen for primary liver cancer

Published in Hepatitis Weekly, December 2nd, 2002

by Sonia Nichols, senior medical writer - Members of a research team headed by doctors at the National Cancer Center in Singapore have concluded tamoxifen is not useful for treating hepatocellular carcinoma (HCC), a primary form of liver cancer.

Although some HCCs carry estrogen receptors, the vast majority do not. Tamoxifen, an estrogen competitor, is best known for the prevention and treatment of breast cancer. Some studies of tamoxifen in HCC have yielded contradictory results. Now, new evidence from an Asian multicenter trial of high-dose tamoxifen in people with inoperable HCC should clear up some of the confusion.

During the trial, 329...

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