Liver Transplantation

Centrilobular fibrosis is not associated with hepatitis in children

Published in Hepatitis Weekly, December 9th, 2002

Viral hepatitis, chronic rejection, and azathioprine toxicity are the primary causes of centrilobular fibrosis after liver transplant in adults. Researchers in Canada explored possible causes of this type of lesion in children, and its prognostic significance, if any.

"We identified centrilobular fibrosis in 12 of 117 pediatric liver transplant recipients who were investigated for persistent elevations in aminotransferases. Etiologic factors, histologic features on serial biopsies, and clinical and biochemical changes over time were noted for eight recipients in whom a readily identifiable cause was not apparent," wrote S.R. Martin and colleagues, Hopital St. Justine,...

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Source: Hepatitis Weekly (2002-12-09)

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