Drug Resistance

Gene transfer sensitizes liver cancer cells to chemotherapy

Published in Hepatitis Weekly, December 9th, 2002

by Sonia Nichols, senior medical writer - Anti-multidrug resistance ribozymes driven by alpha-fetoprotein (AFP) promoters can steer chemosensitivity in hepatocellular carcinomas.

It is not uncommon for cancers to become drug-resistant at some point during chemotherapy, according to Matthes Huesker and colleagues, University Hospital Freiburg, Freiburg, Germany.

"The multidrug resistance (MDR) transporters MDR1-P-glycoprotein and MRP2 (multidrug-associated protein 2) are expressed in almost 50% of human cancers, including hepatocellular carcinomas (HCCs)," Huesker and coauthors explained in Hepatology.

The researchers...

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Source: Hepatitis Weekly (2002-12-09)

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