Hepatocellular Carcinoma

Rel/NF-kappa B transcription factors regulate apoptosis of HCC cells

Published in Hepatitis Weekly, December 23rd, 2002

M.D. Anderson Cancer Center surgical oncologists conducted a study of Rel/NF-kappaB transcription factors to see if they had any regulatory role in human hepatocellular carcinoma (HCC) cells.

Noting that "the mechanism by which HCC cells resist apoptosis induced by various treatment modalities is poorly understood," they "assessed constitutive and inducible activation of NF-kappaB in hepatitis B virus (HBV) positive (Hep3B) and in hepatitis virus negative (Chang, HepG2) HCC, cells, as well as the role of known inhibitors of NF-kappaB activity."

P.J. Chiao and colleagues listed their study findings:

"RelA/NF-kappaB activity is activated...

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Source: Hepatitis Weekly (2002-12-23)

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