Pathology
Role of hepatitis B virus X protein in infection elucidated
Published in Hepatitis Weekly, December 30th, 2002
"The hepatitis B virus X protein (HBx) is essential for viral infection and strongly interferes with cell growth and viability in culture. These activities involve interaction of HBx with the DDB1 subunit of UV-damaged DNA-binding factor UV-DDB. UV-DDB consists of DDB1 and a DDB2 subunit that mediates nuclear import and has recognized functions in DNA repair and E2F1-mediated transcription," researchers in Switzerland report.
In their current study, S. Bontron and colleagues, University of Geneva, "show that HBx retains DDB1-binding-dependent cytotoxic activities when engineered to accumulate in the nucleus but not when excluded from the nucleus."
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Source: Hepatitis Weekly (2002-12-30)
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