Virology

Hepatitis C virus RNA polymerase insertion regions investigated

Published in Hepatitis Weekly, January 27th, 2003

Researchers have analyzed the transmembrane interactions of hepatitis C virus RNA-dependent RNA polymerase.

"The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) belongs to a class of membrane proteins termed tail-anchored proteins," said researchers from Germany.

"Here, we show that the HCV RdRp C-terminal membrane insertion sequence traverses the phospholipid bilayer as a transmembrane segment. Moreover, the HCV RdRp was found to be retained in the endoplasmic reticulum (ER) or an ER-derived modified compartment both following transient transfection and in the context of a subgenomic replicon," wrote N. Ivashkina and colleagues,...

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Source: Hepatitis Weekly (2003-01-27)

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