Transcription

Metals initiate RNA synthesis in hepatitis C virus

Published in Hepatitis Weekly, January 27th, 2003

Magnesium and manganese are just two metals that have been correlated with the synthesis of RNA in viruses such as hepatitis C virus.

"We functionally analyzed the role of metal ions in RNA-dependent RNA synthesis by three recombinant RNA-dependent RNA polymerases (RdRps) from GB virus-B (GBV), bovine viral diarrhea virus (BVDV), and hepatitis C virus (HCV), with emphasis on the HCV RdRp. Using templates capable of both de novo initiation and primer extension and RdRps purified in the absence of metal, we found that only reactions with exogenously provided Mg2+ and Mn2+ gave rise to significant amounts of synthesis. Magnesium (Mg2+) and manganese (Mn2+) affected the...

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Source: Hepatitis Weekly (2003-01-27)

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