Antivirals

Entecavir is superior to lamivudine for reducing hepatitis B virus DNA

Published in Hepatitis Weekly, January 27th, 2003

A study shows entecavir is better than lamivudine for reducing hepatitis B virus DNA levels.

"Entecavir is a novel and selective nucleoside analogue with potent activity against hepatitis B virus (HBV)," researchers in Peoples Republic of China said.

"In a 24-week, double-blind, randomized, multicenter, phase II clinical trial, the safety and efficacy of entecavir (0.01 mg/day, 0.1 mg/day, or 0.5 mg/day orally) were compared with lamivudine (100 mg/day orally). Patients (n = 169) chronically infected with HBV (hepatitis B e antigen [HBeAg]-positive and -negative) were evaluated for efficacy." wrote C.L. Lai and colleagues, Queen Mary Hospital,...

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Source: Hepatitis Weekly (2003-01-27)

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