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Hepatitis B Research

Small peptide dissociates hepatitis B core from surface antigen

Published in Hepatitis Weekly, February 3rd, 2003

Scientists have discovered a peptide that dissociates hepatitis B virus core antigen from hepatitis B virus surface antigen.

According to a study from Malaysia, "M13 phages that display random disulfide constrained heptapeptides on their gpIII proteins were used to select for high affinity ligands to hepatitis B core antigen (HBcAg). Phages bearing the amino acid sequences C-WSFFSNI-C and C-WPFWGPW-C were isolated, and a binding assay in solution showed that these phages bind tightly to full-length and truncated HBcAg with K-D(rel) values less than 25 nM, which is at least 10 orders of magnitude higher than phage carrying the peptide sequence LLGRMK selected from a...

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