Hepatitis E Virus

Antigens from swine or human virus both equally effective in assays

Published in Hepatitis Weekly, February 3rd, 2003

Scientists who work for the United States government have completed a study suggesting the antigenic regions on swine and human hepatitis E viruses are nearly identical.

"The recombinant truncated ORF2 (capsid) antigen derived from the Meng strain of swine hepatitis E virus (HEV) differs from that of the Sar-55 strain of human HEV by approximately 5% at the amino acid level. Serial serum samples from two chimpanzees and six rhesus monkeys experimentally infected with HEV were tested with one enzyme immunoassay (EIA) based on the Sar-55 antigen and with a second EIA based on the Meng antigen. We obtained 98% agreement (kappa=0.952) by direct comparison," researchers in...

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Source: Hepatitis Weekly (2003-02-03)

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