Primary Biliary Cirrhosis
Autoantibody to the transcriptional factor SOX13 high in liver disease
Published in Hepatitis Weekly, February 17th, 2003
"The molecule SOX13 was initially identified as an autoantigen (ICA12) in Type 1 diabetes. SOX13 is a member of the SOX family of transcriptional regulatory proteins that contain a high mobility group (HMG) motif with structural similarity to HMG proteins 1 and 2. Antibodies to HMG 1 and 2 occur in autoimmune diseases of the liver and in ulcerative colitis," the researchers reported.
"We measured the occurrence and levels of anti-SOX13 by radioimmunoprecipitation in primary biliary cirrhosis (PBC) and other diseases, and...
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Source: Hepatitis Weekly (2003-02-17)
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