Hepatitis C Therapy

More sensitive testing indicates low RNA levels may persist after therapy

Published in Hepatitis Weekly, February 17th, 2003

Transcription-mediated amplification-based assays suggest low levels of hepatitis C virus RNA may be present in patients considered sustained responders, researchers in Germany say.

"After treatment of chronic hepatitis C virus (HCV) infection with interferon-alpha + ribavirin in a considerable proportion of patients with a virologic end-of-treatment response (ETR), a relapse during follow-up is observed. The biological background of relapse is unknown. Either antiviral therapy leads to a complete replication arrest and latent virions survive until the end-of-treatment or replication is not completely suppressed," speculated a German research team.

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Source: Hepatitis Weekly (2003-02-17)

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