Hepatitis B Virus
Amino acid residues compatible with hepatitis B virus virion formation
Published in Hepatitis Weekly, February 17th, 2003
According to a study from Germany, "the crystal structure of recombinant hepatitis B virus (HBV) capsids formed by 240 core proteins has recently been published. We wanted to map sites on the surface of the icosahedrall 35-nm particle that are important for nucleocapsid envelopment by HBV surface proteins during virion morphogenesis. For this purpose, we individually mutated 52 amino acids (aa) within the N-terminal 140 aa of the 185-aa long core protein displaying their side chains to the external surface of the capsid to alanine residues."
"The phenotype of the mutations with respect to virion formation was tested, by transcomplementation of a core gene-negative HBV...
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Source: Hepatitis Weekly (2003-02-17)
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