Hepatitis C Genomics

Direct sequence analysis of quantitative PCR products yields good results

Published in Hepatitis Weekly, March 3rd, 2003

According to a study from Italy, "hepatitis C virus (HCV) genotyping, combined with quantitative evaluation of HCV RNA, may be beneficial for the management of chronic hepatitis C and in the selection of candidates for interferon treatment."

"In this study, the COBAS AMPLICOR HCV MONITOR(TM) test, a commercially available quantitative assay for HCV RNA, was used. Amplification products obtained from HCV-positive cases were subjected to direct sequencing and genotyping based on seven phylogenetically informative regions within the 5'UTR," reported F. Gargiulo and coauthors, Spedali Civil Brescia, Virology Laboratory.

"Results were compared with those...

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Source: Hepatitis Weekly (2003-03-03)

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