Liver Failure
Jo2 antibody mediates factors that lead to fulminant hepatitis
Published in Hepatitis Weekly, April 14th, 2003
"The Jo2 anti-mouse CD95 monoclonal antibody induces lethality in mice characterized by hepatocyte death and liver hemorrhage. Mice bearing a defect in Fas expression or in the Fas-mediated apoptotic pathway are resistant to Jo2. Here we show that FcgammaRII knockout mice or mice with monoclonal antibody-blocked FcgammaRII are also resistant to Jo2," according to a study from the United States.
"The critical FcgammaRII+ cells are radioresistant and could not be reconstituted with splenic cells. Death of sinusoidal lining cells and destruction of sinusoids were observed, consistent...
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Source: Hepatitis Weekly (2003-04-14)
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