Hepatitis Coinfection
The synergy of hepatitis B and delta virus antigens activates cell signals
Published in Hepatitis Weekly, April 14th, 2003
"Hepatitis delta virus (HDV) is a naturally occurring satellite of hepatitis B virus (HBV). There are few studies of the effects of the combination of HBV and HDV proteins (HDV antigens [HDAgs]) on intracellular signaling pathways. To understand the influence of HBV and HDV coinfection on hepatocytes, we investigated the effect of HBV proteins and HDAgs on the serum response element (SRE)-dependent pathway," researchers in Japan report.
"Reporter assays revealed that only HBV X protein (HBx), alone or with the large isoform of HDAg (LHDAg), synergistically activated the...
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Source: Hepatitis Weekly (2003-04-14)
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