Virology

Amphiphysin II is a novel partner of the hepatitis C virus NS5A protein

Published in Hepatitis Weekly, April 21st, 2003

"The hepatitis C virus (HCV) NS5A protein is highly phosphorylated by cellular protein kinases. To study how NS5A might be integrated in cellular kinase signaling, we isolated phosphoproteins from HuH-7 hepatoma cells that specifically interacted with recombinant NS5A protein," investigators in Germany report.

"Subsequent mass spectrometry identified the adaptor protein amphiphysin II as a novel interaction partner of NS5A. Mutational analysis revealed that complex formation is primarily mediated by a proline-rich region in the C-terminal part of NS5A, which interacts with the amphiphysin II Src homology 3 domain," wrote B. Zech and colleagues, Axxima Pharmaceutical...

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Source: Hepatitis Weekly (2003-04-21)

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