Virology

HCV NS5A protein and human homeodomain protein PTX1 modulate IFN expression

Published in Hepatitis Weekly, April 28th, 2003

Hepatitis C virus NS5A protein and the human homeodomain protein PTX1 modulate interferon expression, study results show.

"Hepatitis C virus (HCV) NS5A protein transcriptionally modulates a number of cellular genes. Since there is no evidence of binding of NS5A protein to DNA, it is likely to exert its activity in concert with cellular factor(s). ... [W]e have identified a specific interaction of HCV NS5A with homeodomain protein PTX1 of human origin by a yeast two-hybrid interacting cloning system," reported pathologist A.K. Ghosh and colleagues, St. Louis University, Missouri.

The researchers used a mammalian two-hybrid assay, in vivo...

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Source: Hepatitis Weekly (2003-04-28)

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