Hepatitis C Proteomics
Inhibitor-binding site location interferes with hepatitis C virus polymerase
Published in Hepatitis Weekly, May 5th, 2003
"X-ray crystal structures of two non-nucleoside analogue inhibitors bound to hepatitis C virus NS5B RNA-dependent RNA polymerase have been determined to 2.0 and 2.9 Angstrom resolution," according to research from Canada.
"These noncompetitive inhibitors bind to the same site on the protein, similar to 35 Angstrom from the active site. The common features of binding include a large hydrophobic region and two hydrogen bonds between both oxygen atoms of a carboxylate group on the inhibitor and two main chain amide nitrogen atoms of Ser(476) and T yr(477) on NS5B," explained...
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Source: Hepatitis Weekly (2003-05-05)
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