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DNA Vaccine

Transdermal gene delivery eradicates tumors expressing hepatitis C proteins

Published in Hepatitis Weekly, May 5th, 2003

by Sonia Nichols, senior medical writer-A series of research experiments has demonstrated that hepatitis C virus (HCV) DNA vaccine can suppress tumor growth.

The vaccine, developed by researchers at the Karolinska Institute at Huddinge University Hospital in Stockholm, Sweden, contains the genetic components of HCV nonstructural proteins. The gene gun method of delivery appears particularly suited for its administration, researchers report.

"The HCV protease and helicase encompasses the nonstructural (NS)3 protein and the cofactor NS4A, which targets the NS3/4A complex to intracellular membranes," described L. Frelin and coauthors.

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