Published in Hepatitis Weekly, May 12th, 2003
According to a study from Italy, "the up-regulation of tissue transglutaminase (TG2) gene has been shown to occur in various pathologies and can lead to severe liver injury; however, its role in the onset of liver damage has not yet been clarified."
"To address this issue, we have used two experimental settings: carbon tetrachloride (CCl4)-induced liver injury in wild-type and TG2 knockout mice; and liver biopsies obtained from a large cohort of hepatitis C virus (HCV)-infected patients. Mice lacking TG2 failed to clear the hepatic necrotic tissue formed in response to prolonged CC14...
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