Hepatitis C Virus
RNA aptamers inhibit HCV serine protease in living cells
Published in Hepatitis Weekly, May 19th, 2003
"Hepatitis C virus is one of the causative agents of non-A non-B hepatitis. Since one of the viral proteins, NS3, has serine protease activity indispensable for virus maturation. NS3 serine protease is considered to be a suitable target for anti-HCV reagents," scientists in Japan report.
"We report an assay of HCV NS3 protease in living cells. We designed peptide substrates bearing one of the sequences of HCV NS3 protease cleavage sites sandwiched with fluorescent proteins CFP and YFP. Substrates were expressed and cleaved efficiently in HeLa cells by cotransfection with HCV NS3 protease,"...
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Source: Hepatitis Weekly (2003-05-19)
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