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Chronic Hepatitis C

Angiogenic activation in inflamed liver is linked to hepatocyte growth factor

Published in Hepatitis Weekly, May 26th, 2003

by Sonia Nichols, senior medical writer - High levels of hepatocyte growth factor can be detected in the inflamed portal tracts of patients diagnosed with chronic hepatitis C.

Researchers in Spain believe hepatocyte growth factor (HGF) controls angiogenesis in the inflamed liver of people with chronic hepatitis C by modulating growth factors known to regulate endothelial cell adhesion and migration. The knowledge of how proangiogenic mechanisms influence the pathogenesis of chronic hepatitis C could eventually lead investigators to the development of new treatment modalities.

In depth analyses of liver biopsies provided clues for how angiogenic...

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