Virology
RNA ligands bind hepatitis C virus polymerase selectively and block synthesis
Published in Hepatitis Weekly, May 26th, 2003
"To identify the potential RNA inhibitors of HCV polymerise, we have isolated high-affinity RNA ligands specific to hepatitis C virus (HCV) NS5B protein from a combinatorial RNA library using the systematic evolution of ligands by exponential enrichment (SELEX) procedure," researchers in the United States report.
"Thirty-seven selected ligands were classified into eight groups on the basis of their sequence homologies. Most (60%) of the ligands carry the conserved YGUAGR hexAm (Y = pyrimidine, R = purine) at the 5' end of the 40-nt randomized region, and 74% of the ligands...
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Source: Hepatitis Weekly (2003-05-26)
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