Viral Mutation

Woodchuck hepatitis virus class I polymorphism models aspects of hepatitis B

Published in Hepatitis Weekly, June 2nd, 2003

Woodchuck hepatitis virus class I polymorphism models aspects of hepatitis B.

According to recent research published in the journal Tissue Antigens, "the woodchuck (Marmota monax) is an animal model that is used in the study of human hepatitis B virus ( HBV ) infection. A knowledge of woodchuck MHC class I ( Mamo-I ) genes and gene products is therefore essential for understanding the antigen-specific T-cell responses in this animal model. A number of Mamo-I genes have been identified by molecular cloning and sequencing."

"However, the allelic nature of these genes has not been proven by classical genetics like the segregation analysis...

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Source: Hepatitis Weekly (2003-06-02)

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