Liver Cancer

8-Hydroxy-2'-deoxyguanosine levels mark a high risk for cancer recurrence

Published in Hepatitis Weekly, July 7th, 2003

8-Hydroxy-2'-deoxyguanosine levels mark a high risk for cancer recurrence.

According to recent research published in the journal Hepatology Research, "hepatocellular carcinoma (HCC) frequently develops in patients with chronic viral hepatitis and cirrhosis. In these chronic liver disorders, an increased production of reactive oxygen species (ROS) causing oxidative DNA damage has been reported. In this study, we immunohistologically (LSAB method) demonstrated the presence of 8-hydroxy-2'-deoxyguanosine (8-OHdG) that was generated when oxidative DNA damage was caused by active oxygen species in noncancerous region obtained at hepatectomy for HCC, and investigated...

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Source: Hepatitis Weekly (2003-07-07)

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