Published in Hepatitis Weekly, July 21st, 2003
"Of a total of 2342 patients with type-C chronic hepatitis treated with interferon (IFN) at this hospital, 3 patients developed jaundice during the course of IFN therapy, but all 3 of them exhibited negative conversion of hepatitis C virus (HCV)-RNA following re-administration of IFN. All 3 patients were assessed as having 'probable autoimmune hepatitis (AIH)' in accordance with the AIH scoring system, indicating association with an 'autoimmune phenomenon', investigators in Japan reported.
Re-administration of IFN at a low-dose induced activation of the autoimmune...
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