Hepatitis C Virus

Alcohol increases virus in human cells

Published in Hepatitis Weekly, July 28th, 2003

A team of National Institutes of Health-supported researchers report that alcohol increases replication of the hepatitis C virus (HCV) in human cells and, by so doing, may contribute to the rapid course of HCV infection.

The researchers tested the actions of alcohol in HCV replicon - viral HCV-ribonucleic acid or HCV-RNAs that, when introduced into human liver cell lines, replicate to high levels. In separate laboratory experiments they showed that:

1) Alcohol increases HCV replication at least in part by upregulating a key cellular regulator of immune pathways and function known as nuclear factor kappa B (NF-kB).

2) Alcohol...

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Source: Hepatitis Weekly (2003-07-28)

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