Published in Hepatitis Weekly, July 28th, 2003
The researchers tested the actions of alcohol in HCV replicon - viral HCV-ribonucleic acid or HCV-RNAs that, when introduced into human liver cell lines, replicate to high levels. In separate laboratory experiments they showed that:
1) Alcohol increases HCV replication at least in part by upregulating a key cellular regulator of immune pathways and function known as nuclear factor kappa B (NF-kB).
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