Immunology
Hepatitis C virus core proteins induce pro- and anti-inflammatory cytokines
Published in Hepatitis Weekly, July 28th, 2003
According to a study from the United States, "antiviral immunity requires recognition of viral pathogens and activation of cytotoxic and Th cells by innate immune cells. In this study, we demonstrate that hepatitis C virus (HCV) core and nonstructural protein 3 (NS3), but not envelope 2 proteins (E2), activate monocytes and myeloid dendritic cells (DCs) and partially reproduce abnormalities found in chronic HCV infection."
"HCV core or NS3 (not E2) triggered inflammatory cytokine mRNA and tumor necrosis factor (TNF)-alpha production in monocytes. Degradation of I-kappaBalpha...
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Source: Hepatitis Weekly (2003-07-28)
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