Viral Persistence

Peripheral blood dendritic cells appear to be a reservoir for HCV replication

Published in Hepatitis Weekly, August 18th, 2003

Peripheral blood dendritic cells appear to be a reservoir for hepatitis C virus replication during natural infection, study results suggest.

According to researchers in France, "The existence of extrahepatic sites of hepatitis C virus (HCV) replication has been proposed as a mechanism responsible for the poor antiviral immune response found in chronic infection. Dendritic cells (DCs), as unique antigen-presenting cells able to induce a primary immune response, are prime targets of persistent viruses."

N. Goutagny and colleagues, Ecole Normale Super Lyon, purified peripheral blood DCs (PBDCs) from 24 blood samples from patients seropositive for...

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Source: Hepatitis Weekly (2003-08-18)

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