Chronic Hepatitis C
Antigenic escape shifts the antibody balance in hepatitis C-infected patients
Published in Hepatitis Weekly, September 1st, 2003
"This paper investigates the role of cytotoxic T lymphocyte (CTL) and antibody responses in hepatitis C virus (HCV) dynamics and pathology. Mathematical models suggest that a strong CTL response is required for resolution of HCV infection and that a weak CTL response can result in persistent infection. According to the model, establishment of persistent infection is accompanied mainly by an ongoing antibody response, while CTLs are not maintained at high levels."
"In the model, this outcome correlates with absence of pathology. Persistent infection in the face of an...
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Source: Hepatitis Weekly (2003-09-01)
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