Liver Disease

Liver cancers develop spontaneously in mice with hereditary fatty liver

Published in Hepatitis Weekly, September 15th, 2003

Liver cancers develop spontaneously in mice with hereditary fatty liver.

According to published research from Japan, "the fatty liver Shionogi (FLS) mouse is an inbred strain that develops spontaneous fatty liver (hepatic steatosis) chronically without obesity. Here, we reported that the mice develop spontaneous hepatocellular tumors with high incidences. The mice with age of over 1 year frequently developed whitish protuberant nodules in the livers, which were histologically diagnosed as hepatocellular adenoma and/or carcinoma (HCC)."

"An incidence of HCC was 12/30 (40%) in males at 15-16 months of age, while in females that was 0/36 at 13-16 months...

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Source: Hepatitis Weekly (2003-09-15)

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