Viral Proteomics

Crm1 is involved in hepatitis B virus X protein-induced cancer activation

Published in Hepatitis Weekly, September 15th, 2003

Crm1 is involved in hepatitis B virus X protein-induced cancer activation.

According to a study from the United States, "hepatitis B virus (HBV) includes an X gene (HBx gene) that plays a critical role in liver carcinogenesis. Because centrosome abnormalities are associated with genomic instability in most human cancer cells, we examined the effect of HBx on centrosomes. We found that HBx induced supernumerary centrosomes and multipolar spindles."

"This effect was independent of mutations in the p21 gene. Furthermore, the ability of HBV to induce supernumerary centrosomes was dependent on the presence of physiological HBx expression. We recently...

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Source: Hepatitis Weekly (2003-09-15)

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