Hepatitis Therapy

Viramidine pharmacokinetics have been measured in preclinical studies

Published in Hepatitis Weekly, September 22nd, 2003

Viramidine pharmacokinetics have been measured in preclinical studies.

According to recent research published in the journal Antimicrobial Agents and Chemotherapy, "the pharmacokinetics of [C-14]viramidine, a prodrug of ribavirin, were studied in rats (30 mg/kg of body weight) and monkeys (10 mg/kg) following intravenous (i.v.) and oral administration."

"The levels of oral absorption and bioavailabilities were 61.7 and 9.91%, respectively, in rats and 43.9 and 13.6%, respectively, in monkeys. Following i.v. administration, the elimination half-lives were 2.7 hours (h) in rats and 28.9 h in monkeys," reported C.C. Lin and colleagues, Ribapharm...

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Source: Hepatitis Weekly (2003-09-22)

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