Published in Hepatitis Weekly, October 6th, 2003
"We have previously shown that transactivation-proficient hepatitis virus B X protein (HBx) protects Hep 3B cells from transforming growth factor-beta (TGF-beta)-induced apoptosis via activation of the phosphatidylinositol 3-kinase (PI 3-kinase)/Akt signaling pathway. This work further investigated how HBx activates PI 3-kinase. Src activity was elevated in Hep 3B cells following expression of transactivation-proficient HBx or HBx-green fluorescent protein (GFP) fusion proteins," according to researchers in Taiwan."
"The Src family kinase inhibitor PP2 and C-terminal Src...
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